欧宝体育app
请解决为您分析GLP-1 目的体制。GLP-1相结合GLP-1R(1)后,GLP-1R在胰岛β神经上皮细胞中偶联Gas核核蛋白,成功激活卡腺苷环化酶(AC),促成cAMP在神经上皮细胞内含锌量增大,可成功激活卡核核蛋白激酶A(PKA)和cAMP改善的鸟嘌呤核苷酸互相交换指数公式2(Epac-2)。After activation by full agonists such as GLP-1,GLP-1R(1) couples with Gas activates adenolate cyclase(AC),and causes the accumulation of cAMP.With increasing cAMP levels, protein kinase A(PKA) and the exchange protein directly activated by cAMP-2(Epac-2) are also activated.PKA 和 Epac-2 需要关ATP忽略关系于的钾阴阳化合物节点,使神经元膜去极化;还需要激活开通电流值忽略关系于的钙阴阳化合物节点(VDCC)使钙阴阳化合物内流并形成瑜伽动作电势差,等等方式结果英文都将刺激性血糖忽略关系于性胰岛素的分泌出。PKA and Epac-2 trigger the closure of KATP and KV channels,which depolarizes the cell membrane opens voltage-dependent Calcium channels(VDCC) and causes Calcium influx and the promotion of insulin secretion by the islet beta cells